Correlation of Faecal calprotectin with clinical observations
Research type
Research Study
Full title
Investigation into a correlation between a faecal calprotectin result in possible IBD patients with simple clinical observations and whether an initial calprotectin result influences a patients condition over 3 months.
IRAS ID
147302
Contact name
Elizabeth Moorut
Contact email
Clinicaltrials.gov Identifier
NA, NA
Research summary
The aim of the project is to evaluate whether the faecal calprotectin of suspected IBD patients correlates to the simple clinical observations of weight and frequency of bowel movement. The patients will have a follow up sample taken 3 months later to see if the calprotectin has shown a relationship with the clinical observations. Weight and frequency of bowel movement will be used as an indicator of severity of symptoms and calprotectin levels will be compared to see if they correlate and whether calprotectin levels can be used as an indicator or how the patients inflammation progresses. The patients will be recruited through the gastroenterology department in the NHS healthcare setting. Faecal calprotectin is a protein that is produced by neutrophils, these cells form part of the innate immune system and are present at sites of inflammation. Due to the nature of IBD there are areas of inflammation and as a result calprotectin is released into the intestine into the faeces due to the concentration of neutrophils.
REC name
North of Scotland Research Ethics Committee 2
REC reference
14/NS/1013
Date of REC Opinion
19 Jun 2014
REC opinion
Unfavourable Opinion