Correlation Between Peripheral VBG and ABG in Children during GA
Research type
Research Study
Full title
Correlation Between Peripheral Venous and Arterial Gas Analysis in Children during General Anesthesia: \nSingle centre, Prospectical Study; Comparing the Difference Between Peripheral Venous and Arterial Blood Gas Analysis in Children During General Anaesthesia.\n
IRAS ID
211384
Contact name
Graham Bell
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
0 years, 2 months, 31 days
Research summary
Changes in PaCO2 concentration affect cerebral autoregulation. (Meng 2015)\n\nIn particular, hypocarbia is related to poor neurologic outcome in children. (Zhou 2008, Pappas 2011)\n\nThe gold standard for assessing PaCO2 is arterial blood gas analysis (Huttmann 2014)\nBlood samples are taken either via single arterial puncture or an arterial catheter. Relative contraindications include bleeding diathesis or disturbance of clotting factors. Arterial puncture requires expertise and skill, and can be painful for the patient. It is also a time-consuming process that carries a risk for infection and damage of tissue, nerves, and vessels (Flenley 1908).\n\nKim et all showed that peripheral venous PvCO2 may be used as alternative for the arterial values, in adults. (Kim 2013) There are currently no studies in children.\n\nThe aim of this study is to investigate if the correlation of PaCO2 and peripheral PvCO2 is sufficient in clinical practice. If a good correlation exists further studies investigating the relationship of PvCO2 and ETCO2 in paediatric patients during general anaesthesia are planned.\n\n
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
16/NW/0767
Date of REC Opinion
15 Nov 2016
REC opinion
Further Information Favourable Opinion