Correlation between MYMOP and LARS in assessing progress of treatment.
Research type
Research Study
Full title
Prospective study to assess correlation between Measure Yourself Medical Outcome Profile (MYMOP) and Low Anterior Resection Syndrome (LARS) Questionnaires in assessing progress of bowel dysfunction in patients post anterior resection surgery for rectal cancer
IRAS ID
324937
Contact name
Samer Mashlab
Contact email
Sponsor organisation
Ashford and St Peter's Hospitals NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
This study aims to assess if the MYMOP tool, (Measure Yourself Medical Outcome Profile) correlates to the current tool, Low Anterior Resection Syndrome (LARS) Score, in assessing progress of treatment in patients treated for LARS.
We have observed that the LARS Score is a good tool to identify and stratify LARS, however doesn’t always correlate with patients expressed progress after treatment is started. This discordance between LARS Score and patient actual progress makes it harder for clinicians to guide their treatment. MYMOP questionnaire is a patient driven tool which allows focus on the most troublesome symptoms chosen by the patient to be addressed. We anticipate that this tool will provide the clinician a clearer focus on treatment which will translate into a more effective consultation and positive experience for patients.
LARS is a sequelae of surgical and oncological (radiotherapy) treatment of rectal cancer. Over the past 40 years, overall 5 year net survival from colorectal cancer has increased from 22% to 57% (www.cancerresearchuk.org), along with advancement in surgical technique, the sequelae of treatment are becoming of more importance for both patients and clinicians. Low anterior resection syndrome may consist of faecal and gas incontinence, urgency, frequent bowel movements, clustering of stools, and difficulty emptying. These symptoms lead to a myriad of consequences which include preoccupation with bowel function, toilet dependence, relationships and intimacy, social and daily activities, all which have an impact on mental and emotional wellbeing.Patients identified to have LARS will be eligible to take part in this study. Screening and recruitment of participants along with completion of these questionnaires will take part in dedicated bowel dysfunction after surgery clinics at our hospitals. The total duration of the study is 12 months. Each participant will be followed up for 5 months from recruitment.
REC name
North East - York Research Ethics Committee
REC reference
23/NE/0050
Date of REC Opinion
16 Mar 2023
REC opinion
Further Information Favourable Opinion