Correlation between Aldosterone Levels and Oedema in Heart Failure
Research type
Research Study
Full title
Correlation between Aldosterone Levels and Clinical Presentation in a Series of Patients Admitted with Acute Heart failure a- Preliminary Investigation
IRAS ID
132742
Contact name
Robert N Stevenson
Contact email
Sponsor organisation
Calderdale and Huddersfield Foundation Trust
Research summary
Acute heart failure is the most common cause of hospital admission amongst patients over 65 years of age. Diuretic treatment (water tablets) are key in managing symptoms due to fluid retention. A type of diuretic which block the effect of the hormone aldosterone (aldosterone antagonists) are currently used in low dosages, and it is uncertain whether higher doses would lead to further benefit particularly in patients with gross oedema (fluid retention). Speculatively, it may be appropriate to target patients according to pretreatment levels of aldosterone though this is not current clinical practice.
The purpose for this study is to establish the degree of variation in baseline aldosterone levels in a series of consecutive patients presenting with acute decompensated heart failure and to identify any correlation with a number of predefined clinical parameters, in particular the degree of peripheral oedema. The degree of oedema is to be measured using an established objective scoring system).
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
13/YH/0302
Date of REC Opinion
4 Sep 2013
REC opinion
Further Information Favourable Opinion