CorMicA-PCI
Research type
Research Study
Full title
Angina after PCI: a systems medicine study.
IRAS ID
271025
Contact name
Colin Berry
Contact email
Sponsor organisation
NHS Golden Jubilee
Duration of Study in the UK
19 years, 11 months, 31 days
Research summary
Angina may persist or recur in 1 in 3 patients treated by coronary angioplasty. The angioplasty involves a balloon treatment to open a blocked heart blood vessel and usually a stent (thin metal tube) is placed. Stents do not always improve symptoms and may make symptoms worse. Sometimes a drug-eluting-balloon is used instead of a stent. This balloon coats the inside of the blood vessel to prevent re-narrowing.
Research is needed to clarify the causes of ongoing angina and its impact on patients and the NHS, and to identify which patients will or will not benefit from a stent (hence avoiding over-treatment in the future).
We plan a 5-year UK-wide study involving 600 patients with angina undergoing coronary angioplasty (with or without a stent). They will initially have a heart MRI scan. We will assess what might influence the recurrence of angina in the year after the angioplasty procedure. We will measure small blood vessel function in the heart and the amount of plaque persisting after PCI.
Patients who report angina after coronary angioplasty usually have a second invasive angiogram. Instead, we will invite patients to have a heart MRI scan allowing us to also assess whether this scan might be more useful than a repeat angiogram in guiding clinical care.
We will then use health economics to assess NHS resource use and costs, and whether the MRI scan approach might be cost-saving. The study involves follow-up contacts for up to one year after the angioplasty, and then follow-up using electronic health record linkage without contacts.
Participants will also be invited into brain imaging substudy of chronic chest pain. Up to 120 participants will be invited with a 2:1 pain: no pain distribution. This substudy aims to provide information on the brain pathways involved in chronic angina after angioplasty.
REC name
West of Scotland REC 5
REC reference
24/WS/0033
Date of REC Opinion
16 Apr 2024
REC opinion
Further Information Favourable Opinion