COPD patients using capsule DPIs

• Research type

  Research Study

• Full title

  Characterisation of the inhalation manoeuvre when COPD patients use 3 different capsule dry powder inhalers

• IRAS ID

  152722

• Contact name

  Henry Chrystyn

• Contact email

  h.chrystyn@hud.ac.uk

• Sponsor organisation

  University of Huddersfield

• Research summary

  Most patients with chronic obstructive pulmonary disease use drugs delivered from an inhaler to help them with their shortness of breath and improve their quality of life. An inhaler is not easy to use. Patients with chronic obstructive pulmonary disease have a reduced capacity to inhale and so it is important that the inhalers they are prescribed can be used by them.
  This study has been designed to measure how patients with chronic obstructive pulmonary disease inhale through three different dry powder inhalers. During normal use, these inhalers require the patient to insert a dose into the device. The dose is contained in a capsule. The patient presses a button on the device which pierces the capsule. They then inhale to empty the capsule contents into the airstream as they inhale.
  There are different types of these inhalers. One that is available is the Handihaler, which delivers tiotropium, while others are being developed; two of these are called the Zephir and the Zonda. Using the method of inhalation recommended by the manufacturer of these inhalers we will instruct patients with chronic obstructive pulmonary disease how to inhale through each one. We will then put an empty capsule into each one and ask the patient to inhale through the device according to our instructions. Each patient will make two separate inhalations with each device. A tube will link each inhaler to a computer so that we can measure each inhalation. These inhalations will enable us to identify the dose the patient would have received if a drug was inside the capsule.
  Each patient will make two separate inhalations through three different inhalers. The inhalers will be empty and so the patient will not inhale any medication

• REC name

  Yorkshire & The Humber - Bradford Leeds Research Ethics Committee

• REC reference

  14/YH/0121

• Date of REC Opinion

  23 May 2014

• REC opinion

  Further Information Favourable Opinion