Contributions of physical activity, diet in development of macrosomia
Research type
Research Study
Full title
Contributions of physical activity, diet and their composition in pregnancy to the development of foetal macrosomia (Large babies with weight over 4kg).
IRAS ID
184503
Contact name
Oluwafemi/O George
Contact email
Sponsor organisation
Anglia Ruskin University
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 7 months, 3 days
Research summary
BACKGROUND: \nAn increasing proportion of women are giving birth to macrosomic babies worldwide, that is, babies with birth weight above either 4kg or 95th percentile for a specific gestational age (Ornoy, 2011). These women and their children have increased risk of health problems during delivery and in later life (Jolly et al., 2003; Henriksen, 2008; Voldner et al., 2009). The risk factors in pregnant women include obesity, sedentary lifestyle, high blood sugar (Han, Middleton and Crowther, 2012). \nThere is evidence that physical activity and/or diet modification are associated with reduction in delivery of macrosomic babies (Thangaratinam, et al., 2012). These associations remain unclear and too broad because previous studies focussed on energy balance from diet and/or physical activity in pregnancy (Redfern, Rees and Pinkney, 2016). Furthermore, Montpetit et al., (2012) and Olsen et al (2007) showed possible associations of specific forms of physical activity and diet, rather than their energy content to development of foetal macrosomia in pregnancy. There is presently no observational study of physical activity and diet, throughout pregnancy in free-living healthy pregnant women, to determine the contributions of the quality and forms of physical activity and dietary Intake to the development of foetal macrosomia. This study’s aim is to achieve this and bridge the gap in knowledge. \nMETHOD \nThe research will use questionnaires, accelerometers and semi-structured interviews to obtain data on physical activity and diet from a total of 292 pregnant women, recruited across 3 NHS maternity trusts. This will be compared with offspring weight to determine associations. \nELIGIBILITY CRITERIA\nEligible women for the study must be 18 and above, pregnant with a single foetus, that has no physical or structural defect, genetic or metabolic anomalies. The women should also have no previous diagnosis of diabetic mellitus, and abnormalities present at birth in children from previous pregnancies. \n\nREFERENCES\nKramer, M.S., 2003. “The epidemiology of adverse pregnancy outcomes: an overview,” Journal of Nutrition [Online] Available at: <http://jn.nutrition.org/content/133/5/1592S.full> [Accessed 20 March 2014].\nHan, S., Middleton, P., Crowther, C.A., 2012. Exercise for pregnant women for preventing gestational diabetes mellitus. Cochrane Database of Systematic Reviews [Online] Available at: <http://summaries.cochrane.org/CD009021/exercise-for-pregnant-women-for-preventing-gestational-diabetes-mellitus#sthash.ztcRrHVH.dpuf> [Accessed 19 March 2014]. \nThangaratinam, S., Rogozińska, E., Jolly, K., Glinkowski, S., Roseboom, T., Tomlinson, J.W., Kunz, R., Mol, B.W., Coomarasamy, A., Khan, K.S., 2012. Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence.BMJ [Online] Available at: <http://www.bmj.com/content/344/bmj.e2088> [13 March 2014].\nVoldner, N., Frøslie, K.F., Haakstad, L.A.H., Bø,K. and Henriksen, T., 2010. “Birth complications, overweight, and physical inactivity,” Acta Obstetricia et Gynecologica Scandinavica [Online] Available at: < http://onlinelibrary.wiley.com/doi/10.1080/00016340902818162/abstract> [Accessed 20 March 2014]. \nHenriksen, T., 2012. “The macrosomic fetus: a challenge in current obstetrics,” Acta Obstetricia et Gynecologica Scandinavica [Online] Available at: <http://onlinelibrary.wiley.com/doi/10.1080/00016340801899289/full> [Accessed 20 March 2014].\nØrskou, j., Kesmodel, U., Henriksen, T.B. and Secher, N.J., 2001. “An increasing proportion of infants weigh more than 4000 grams at birth,” Acta Obstetricia et Gynecologica Scandinavica [Online] Available at: <http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0412.2001.801010.x/abstract> [Accessed 19 March 2014].\n
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
17/NW/0383
Date of REC Opinion
20 Jun 2017
REC opinion
Further Information Favourable Opinion