Contribution of muscle and liver glycogen storage during daily eating
Research type
Research Study
Full title
Assessment of day-long skeletal muscle and liver glycogen storage, and pancreas and liver composition in people with nornal glucose tolerance
IRAS ID
127990
Contact name
Roy Taylor
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Research summary
Understanding the process of storing carbohydrate as glycogen after a meal, and the release of glucose from glycogen stores when required is crucial in maintaining normal glucose concentration. In normal individuals, about 30% of carbohydrate is stored as muscle glycogen after a single meal, and peak concentrations are observed around 5 hours, declining thereafter; whereas 20% of absorbed carbohydrate is incorporated in liver glycogen within the same time course. As such, muscle and liver glycogen storage acts as a buffer, storing large amounts of glucose after a meal and this prevents blood sugars rising to very high levels. However the day-long buffering capacity of skeletal muscle and liver glycogen stores have not been previously examined in subjects with normal glucose tolerance.
In order to be able to compare the extent of abnormal skeletal muscle and liver glycogen dynamics in type 2 diabetes, as measured in the Vildagliptin CLAF 237A2389 study, a group of normal glucose tolerance volunteers will be studied.
The normal glucose tolerance volunteers will be matched for age, sex and BMI with type 2 diabetes mellitus subjects studied in the Vildagliptin CLAF 237A2389 study. By carrying out identical assessments of muscle and liver glycogen, this study will enable normal physiological concepts to be defined, as a basis for understanding the process of dealing with meal time carbohydrate.REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
13/NE/0208
Date of REC Opinion
2 Sep 2013
REC opinion
Favourable Opinion