Construction of an ophthalmic cell model for regenerative medicine

• Research type

  Research Study

• Full title

  Construction of a novel, perfusion-based, ophthalmic cell model for regenerative medicine and drug development

• IRAS ID

  159483

• Contact name

  David Chau

• Contact email

  d.chau@herts.ac.uk

• Sponsor organisation

  University of Hertfordshire

• Research summary

  The aim of this research is to develop a perfusion-based (i.e. flowing), biologically representative model of the eye using human cells, novel constructs and additional biomaterials. It is anticipated that this model may be used for: (i)the identification and determination of cell behaviour/mechanisms, (ii) applications in regenerative medicine and drug development i.e. formulation, and (iii) toxicity assessment of new compunds and disease modelling (e.g dry eyes).

  It is anticipated that this project will provide several distinct outcomes:
  1. Fundamental science: better understanding of cell interactions, identification of key mechanisms involved in disease development, determination of drug uptake/breakdown pathways
  2. Feasible development of therapeutic end-product(s) for regenerative medicine
  3. Development of basic platform technology which may be used as a standard (toxicity) test-model for eye research and product development

• REC name

  London - Westminster Research Ethics Committee

• REC reference

  14/LO/1475

• Date of REC Opinion

  19 Aug 2014

• REC opinion

  Further Information Favourable Opinion