Complement mediated allograft nephropathy - version 1
Research type
Research Study
Full title
Alloantibody and complement deposition mediated activation of pro-inflammatory signalling pathways in human renal and cardiac disease
IRAS ID
150438
Contact name
John R Bradley
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Research summary
Chronic rejection accounts for the majority of cases of late loss of transplanted organs. It is characterised by remodelling of blood vessels within the transplant, with progressive occlusion of the vessel lumen. The exact mechanisms, and hence treatment, are unclear but the process occurs more frequently in patients who have developed antibodies against the donor's tissue. Recent studies using cultured cells and animal models have shown that the deposition of antibody and the pro-inflammatory protein complement on endothelial cells lining blood vessels can activate specific pro-inflammatory signalling pathways that trigger the vascular changes seen in chronic rejection. This study aims to determine whether these signalling pathways are activated in archived anonymised kidney and heart tissue when antibody and complement are present.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
14/LO/1025
Date of REC Opinion
2 Jun 2014
REC opinion
Favourable Opinion