Comparison of lidocaine vs. pregabalin in CRPS, type 1

• Research type

  Research Study

• Full title

  A Single Blind, Randomised, Cross-over Study to Compare the Efficacy of Lidocaine 5% Plasters (Versatis®) versus Pregabalin (Lyrica®) in the Treatment of Complex Regional Pain Syndrome, Type 1.

• IRAS ID

  89153

• Contact name

  Michael Gregory

• Sponsor organisation

  The Pennine Acute Hospitals NHS Trust

• Eudract number

  2009-010557-12

• Research summary

  This study aims to compare the use of lidocaine 5% plasters versus pregablin capsules in the management of complex regional pain syndrome, type 1. This type of pain develops after a tissue injury and normally affected a limb e.g. legs, arms. The mainstay of treatment is restoration of normal movement and function of the affected limb. Recent small studies in peripheral neuropathic pain have shown that the application of a topical local anaesthetic (lidocaine plasters) onto the painful skin area appears to be effective and safe. The current published clinical evidence also supports the use of tricyclic antidepressants, certain opioids, gabapentin and pregabalin in neuropathic pain. This study plans to compare the 2 treaments to find out which gives the best pain relief to the patients. This study will be conducted on patients who attend the NHS pain clinic situated in Dr Kershaw's Hospice, Oldham. 20 patients will be randomised and the total study participation time is 5 months.

• REC name

  North West - Liverpool Central Research Ethics Committee

• REC reference

  11/NW/0758

• Date of REC Opinion

  1 Mar 2012

• REC opinion

  Further Information Favourable Opinion