Comparison of lid/bicarb/epi with lid/epi/fen for LSCS. Version 1
Research type
Research Study
Full title
A randomised comparison of mixtures of lidocaine/bicarbonate/epinephrine with lidocaine/epinephrine/fentanyl when used for epidural top up for emergency caesarean section after “low dose” epidural analgesia during labour.
Sponsor organisation
Hull and East Yorkshire Hospitals NHS Trust
Eudract number
2009-010944-32
ISRCTN Number
n/a
Research summary
The preferred anaesthetic technique for emergency caesarean section is under epidural or spinal anaesthesia. Epidural analgesia remains the most effective form of pain relief for labour and, in our unit 40% of women in labour request this form of analgesia. Should such a woman require an emergency lower segment caesarean section, it is a standard practice to use an epidural injection of a stronger local anaesthetic to provide anaesthesia for surgery. An important issue with epidural injection for such patients is the time required to prepare the drugs and the time required for the drugs to work. Our standard mixture consists of three drugs, one of which is kept in a locked cupboard by law. Obtaining the keys can waste valuable time. The drug mixture we wish to compare with our standard drug mixture contains drugs which do not need to be kept in a locked cupboard.We wish to find out if the preparation time and the time required for this drug to work is faster than our standard drug mixture.The study is a prospective randomised double blind study to be conducted in the Women and Children Hospital, Hull Royal Infirmary.All patients having an epidural sited for pain relief in labour, once pain-free, will be approached regarding the study and their written informed consent obtained. No external funding has been sought and will be based in one Acute teaching NHS Trust.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
09/H1306/55
Date of REC Opinion
15 Jun 2009
REC opinion
Further Information Favourable Opinion