Comorbidities and Outcomes in Chronic Pancreatitis
Research type
Research Study
Full title
Comorbidities and outcomes of patients with chronic pancreatitis: a single centre cohort study
IRAS ID
298131
Contact name
Aloysious Aravinthan
Contact email
Sponsor organisation
Nottingham University Hospitals NHS Trust
Duration of Study in the UK
7 years, 11 months, 31 days
Research summary
BACKGROUND: Chronic pancreatitis is an inflammatory condition characterized by scarring and inflammation of the pancreas in individuals with genetic, environmental, and other risk factors such as excess alcohol intake or hypertriglyceridemia. Life expectancy in chronic pancreatitis is diminished compared with control populations with median survival reported to be 15 to 20 years after diagnosis. Survival is affected by complications of chronic pancreatitis, adverse effects of alcoholism, smoking, and diabetes.
A previous study showed a standardized incidence ratio (SIR) of 26.3 (95% CI, 19.9-34.2) for pancreatic cancer in patients with CP. The cumulative risk of pancreatic cancer was 1.8% at 10 years and 4% at 20 years of follow-up. Further, studies highlight an increased prevalence of osteoporosis, cardiovascular events and inflammatory bowel disease in patient with CP. However, very little contemporaneous data exists on the UK population. In addition, little is known about the prevalence of other comorbidities such as non-pancreatic cancers, dementia, depression, multi-organ fibrosis, multi-morbidity etc.
Nottingham University Hospitals NHS Trust (NUH) is a tertiary referral centre for chronic pancreatitis, which would enable a large cohort study to be undertaken to understand the epidemiology, associated comorbidities and outcomes of patients with chronic pancreatitis.RATIONALE: The findings of this study aim to increase understanding of comorbidities associated with chronic pancreatitis, benefiting both clinicians and patients. By identifying prevalent comorbidities and associated risk factors, recommendations for potential interventions can be made.
The aim of this study is to combine routinely collected clinical data, GP summary Care Records, Hospital Episode Statistics - NHS Digital data, with nationally collected data from the Office for National Statistics, Clinical Practice Research Datalink, National Cancer Registration and Analysis Service and the Personal Demographics Service - NHS Digital. By combining all these data sources, we will be able to establish long-term clinical outcomes and associated comorbidities for patients with chronic pancreatitis.REC name
Wales REC 5
REC reference
22/WA/0074
Date of REC Opinion
24 Mar 2022
REC opinion
Favourable Opinion