Combatting non communicable diseases through enhanced surveillance
Research type
Research Study
Full title
CODIET: Combatting diet related non-communicable disease through enhanced surveillance.
IRAS ID
330755
Contact name
Gary Frost
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
0 years, 5 months, 0 days
Research summary
Unhealthy diets are associated with metabolic changes and increased risk of non-communicable diseases (NCDs). However, current understanding of the relationship between diet and the development of NCDs is limited by a number of factors. These include a lack of understanding of dietary mechanisms that drive NCD, inaccurate tools to collect dietary information, a nascent understanding of the role of personalised nutrition, and the lack of data in vulnerable groups where NCDs are often over-represented.
The relationship between dietary intake and the development of NCDs is complex. The understanding of how diet relates to development of metabolic risk factors on a background of non-modifiable risk factors is improving with the greater understanding of the metabolic pathways that are responsive to dietary profile and lead to change in NCD risk. Tools that profile the genome, metabolome, epigenome, microbiome and inflammation are key to understanding the impact of diet on NCDs. However, these systems are mostly studied in isolation and their relative importance of how they interact with each other is not understood.
We will focus on the relationship between diet and cardio metabolic risk factors (raised blood pressure, increased blood glucose, elevated blood lipids and central obesity) as a portfolio of risk factors that drive a number of NCDs including type 2 diabetes, coronary vascular disease, number of cancers and dementia.
The aim will be to assess:
1- How camera technology and metabolomics enhance traditional dietary reporting against established biomarkers
2- How new technologies, genotype, metabolomics, microbiota, epigenetics, inflammatory response enhance the understanding on metabolic pathways to NCD risk.
REC name
London - Surrey Research Ethics Committee
REC reference
23/PR/1109
Date of REC Opinion
3 Nov 2023
REC opinion
Further Information Favourable Opinion