Collaborative Biorepository for Translational Medicine (CBTM)

• Research type

  Research Tissue Bank

• IRAS ID

  274524

• Research summary

  Collaborative Biorepository for Translational Medicine (CBTM) – A Resource of Viable Tissues to Support Biomedical Research

• REC name

  East of England - Cambridge Central Research Ethics Committee

• REC reference

  20/EE/0106

• Date of REC Opinion

  2 Jun 2020

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  Tissue samples will be stored at Level E9, Department of Surgery, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ. Additional sites may include appropriate locations at Cambridge University Hospitals NHS Trust or on Cambridge Biomedical Campus. Samples may be transferred to other accredited facilities (to be determined) for long-term storage.

• Research programme

  Key collaborating institutions will include but are not limited to: • University of Cambridge. Research conducted by collaborators from the University of Cambridge will include but not limited to the study of normal or pathological cellular and organ physiology, regenerative medicine and cancer. • Human Cell Atlas (HCA) consortium and affiliated research institutions. The aim of research by this consortium is to generate a reference of all human cells, including how cell types work together to form tissues, knowledge of how all body systems are connected and insights into how changes in the map underlie health and disease. HCA affiliated institutions may include institutions in the UK, Europe, USA and Asia. • The Wellcome Sanger Institute. The aim of research by the Wellcome Sanger Institute includes (but is not limited to) using DNA and RNA sequencing to understand hallmarks of disease. • AstraZeneca. Research conducted in collaboration with AstraZeneca will include immunology of cancer and the safety and efficacy of cancer immunotherapies. • Galvani and GSK. Research conducted in collaboration with Galvani and GSK will include understanding the regulation of the immune system by the autonomic nervous system. • The Milner Institute. Research conducted in collaboration with the Milner Institute will include using Bioinformatics and Machine Learning to identify signatures of disease from genomic data. • University of Edinburgh. Research conducted in collaboration with the University of Edinburgh will include studies into liver disorders and transplantation. Donor families will have the option to exclude (i.e., opt out) studies that are conducted in collaboration with commercial organisations.

• Storage license

  12315

• RTBTitle

  Collaborative Biorepository for Translational Medicine (CBTM) – A Resource of Viable Tissues to Support Biomedical Research

• Establishment organisation

  Cambridge University Hospitals NHS Foundation Trust

• Establishment organisation address

  Cambridge Biomedical Campus

  Hills Road

  Cambridge

  CB2 0QQ