Cognitive performance among men receiving ADT
Research type
Research Study
Full title
Risk and Resilience Factors Associated with Cognitive Changes Following Androgen Deprivation Therapy in Prostate Cancer Patients
IRAS ID
174977
Contact name
Ian Marshall
Contact email
Sponsor organisation
Coventry University
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
Prostate cancer survivors receiving long-term androgen deprivation therapy (ADT) experience unpleasant and debilitating side-effects, including decline in cognitive function. There are no studies examining the risk/resilience factors for cognitive decline among men prescribed ADT. This study aims to identify risk and resilience factors for cognitive decline among men receiving ADT through a prospective design utilising mixed methods: neuropsychological tests (e.g. tests of memory), brain imaging (to obtain hippocampal volumes; resting state activity; task- related activity), psychosocial measures (i.e. mood, self-reported cognitive function, social networks) and blood biomarkers (e.g. APOE genotyping, baseline testosterone). 102 men receiving ADT and 51 prostate cancer patients not receiving ADT will complete neuropsychological tests, psychosocial questionnaires and a brain-scan (pre-treatment) and repeat the brain-imaging at 6 months and neuropsychological assessments and psychosocial measures at 6 and 18 month follow-ups. Logistic regression will be utilised to assess baseline factors leading to change in cognitive performance in ADT patients (dichotomised as decline in performance (risk group) versus same/improved performance (resilience group)). Results would provide crucial information to support prostate cancer patients’ treatment decision-making, support clinical recommendations regarding prescribing if contraindications are suggested and support the development of interventions to mitigate the impact of cognitive change among men receiving ADT
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
15/WM/0338
Date of REC Opinion
20 Nov 2015
REC opinion
Further Information Favourable Opinion