Cognition in Cystic Fibrosis patients and matched controls (Version 1)
Research type
Research Study
Full title
Cognition (memory, attention and executive function) in Cystic Fibrosis patients (with/without CF related diabetes) and matched controls
IRAS ID
116852
Contact name
Helen Chadwick
Contact email
Sponsor organisation
Leeds Teaching Hospital NHS Trust
Research summary
Cystic Fibrosis (CF) is the most common autosomal recessive disease affecting Caucasians, with 1 in every 25 people being a carrier. CF is the result of a single gene mutation on the long arm of Chromosome 7, which is responsible for the function and production of a protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Cystic Fibrosis-Related Diabetes Mellitus (CFRD) is a distinct type of diabetes. It is an important complication which has become apparent in people with CF due to increased longevity. Impaired Glucose Tolerance (IGT) as well as Type 1 and 2 diabetes have been associated with cognitive impairments (problems with memory, attention, problem solving). At present, there is no research to suggest that impairments are apparent in patients with CFRD. Given that CFRD shares some clinical characteristics of both Type 1 and 2 diabetes, it would be reasonable to suggest cognitive impairment may be apparent in this diabetes population.
This study will investigate cognitive function (memory, attention, executive function) using a touch-screen computer (CANTAB) in matched Cystic Fibrosis patients (insulin-treated CFRD and CF non-diabetic (CFND) patients) and healthy controls to determine which aspects of cognition are potentially impaired in patients with CF. The study will take place at St James’s Hospital, Leeds (Cystic Fibrosis Unit) or at Seacroft Hospital Leeds, (Outpatients Clinic) for patients who have CF. Healthy controls will be tested at the Human Appetite Research Unit, Institute of Psychological Sciences, University of Leeds to minimise inconvenience to the Cystic Fibrosis Unit.
CF participants will be recruited from the Leeds Adult Regional Centre, and the healthy controls through their unaffected family or friends, or the Leeds population. Participants will attend one testing session, where they will complete a series of cognitive tests and several short questionnaires about their wellbeing and the study, and then debriefed.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
13/YH/0219
Date of REC Opinion
20 Aug 2013
REC opinion
Further Information Favourable Opinion