Coffee consUmption in People with Liver Disease (CUPLID) v1
Research type
Research Study
Full title
Exploring Coffee consUmption in People with Non-Alcoholic Fatty Liver Disease and understanding barriers and enablers to increasing their intake (CUPLID)
IRAS ID
223905
Contact name
Robin G Poole
Contact email
Sponsor organisation
University of Southampton
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
There is some evidence to suggest that drinking coffee is linked to a lower risk of liver disease. However, the current evidence for this is limited due to the types of studies used, and we cannot rely on this to tell us whether people with liver disease might experience benefit from drinking more coffee or not.
More research is needed to help us find this out. This is important because there are currently very limited treatment options for some liver diseases. The first part of this research (the present study) is designed to find out more about the patterns of coffee drinking that already exist in people with liver disease, their views about drinking more coffee, and opinions on our proposed future research.
We would like to achieve this by conducting approximately 20-32 semi-structured interviews and 384 questionnaires with people with Non-Alcoholic Fatty Liver Disease (NAFLD). This is a type of liver disease in which fat accumulates in the liver, and for a small proportion, this will progress to liver fibrosis and cirrhosis, irreversibly scarring the liver or increasing the risk of hepatocellular carcinoma (HCC).
Suitable adult patients receiving care from liver outpatient clinics will be invited to take part in the interviews or surveys. The interviews will take the form of one-on-one conversations and will last approximately 30-60 minutes. Key themes from the interviews will help us design the final version of the questionnaire that will explore the same issues in a larger, representative sample, of approximately 384 people with NAFLD.
Findings from the interviews and the survey will be combined to draw final conclusions that will be used to help us plan a future randomised controlled trial to find out if drinking more coffee could beneficially improve the long-term outcomes for people with NAFLD.
REC name
West of Scotland REC 5
REC reference
17/WS/0231
Date of REC Opinion
10 Nov 2017
REC opinion
Favourable Opinion