COAST: studying cough in asthma phenotypes
Research type
Research Study
Full title
Studying Cough in Asthma Phenotypes
IRAS ID
126945
Contact name
Imran Satia
Contact email
Sponsor organisation
University Hospital of South Manchester NHS FT
Research summary
Asthma is a common disorder of the small tubes (airways) that carry air in and out of the lungs.
Patients with asthma intermittently complain of symptoms of wheeze, cough, shortness of breath, and chest tightness during attacks of asthma. However, some asthmatics do not describe all of the classical symptoms detailed above whilst others only have one predominant symptom, such as cough. Some patients have symptoms triggered by different things like pollen, cold air, exercise or taking medication like aspirin or ibuprofen.
We also now realise that some asthmatics respond to treatment in different ways or develop asthma at different ages. This has led doctors to realise that asthma is not one disease but a group of different diseases and we need to better understand the actual mechanism of how asthma patients experience symptoms within these groups.
Our research interest is that of understanding cough in a well characterised group of asthmatics. We hope to show difference in cough responses within asthmatics, particularly allergic and non-allergic asthmatics. This research could therefore help us develop new medications to specifically target cough in asthmatics.
In this study we aim to recruit 100 people with with stable mild to moderate asthma to attend 3 study visits at either Wythenshawe Hospital or the Wellcome Trust Clinical Research Facility, depending on their locality. Study visits will involve asthma phenotyping tests, a blood test, 24hr cough monitoring and a capsaicin challenge, which are described in detail in the participant information sheet.
REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0403
Date of REC Opinion
2 Jul 2013
REC opinion
Favourable Opinion