COAGULUM
Research type
Research Study
Full title
The Coagulation Investigation Network- Understanding Mechanisms (COAGULUM);Investigation of the aeitology and prognosis of venous thromboembolism or those at risk of it.
IRAS ID
209690
Contact name
Reecha Sofat
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
Venous thromboembolism (VTE) is the third most common vascular disease after heart disease and stroke. The term VTE encompasses formation of clot in the deep veins of the legs or pelvis (deep vein thrombosis, DVT) and their displacement to the arteries in the lungs (pulmonary embolism, PE). Whilst some causes of VTE are understood, for example immobility (e.g. secondary to a long haul journey, following surgery), it is unclear why some individuals get VTE whereas others exposed to the same conditions do not. Similarly we understand some of the rare genetic conditions that predispose to increased risk of VTE although this picture is likely to be incomplete. Moreover, understanding the prognosis of individuals that suffer VTE at scale is unstudied, and how to best predict and prevent recurrences still remains unknown. In this study we aim to investigate the causes and consequences of VTE using genetic studies, studies of circulating factors in the blood, and linked electronic health record research, to enable us to collect information on longer term outcomes. With this we aim to contribute to the prevention and improved prognosis of those with VTE.
REC name
London - Queen Square Research Ethics Committee
REC reference
17/LO/0107
Date of REC Opinion
24 May 2017
REC opinion
Further Information Favourable Opinion