CMS Study
Research type
Research Study
Full title
NORDIC (and UK) STUDY OF THE CEREBELLAR MUTISM SYNDROME (CMS) IN CHILDREN WITH BRAIN TUMOURS OF THE POSTERIOR FOSSA
IRAS ID
210149
Contact name
Conor Mallucci
Contact email
Sponsor organisation
Alder Hey Children's NHS Foundation Trust
Duration of Study in the UK
3 years, months, days
Research summary
Central nervous system (CNS) tumours constitute 25% of all childhood cancers, and more than half of these are located in the cerebellum. One of the most troublesome late effects after operation for such a tumour is the cerebellar mutism syndrome (CMS) which is seen in up to 25% of children after surgery. It is characterized by mutism, hypotonia, ataxia and irritability, and the exact causes have yet to be identified.\n\nThe purposes of this study are to uncover: 1) which surgical methods are least likely to cause the CMS and if there is a difference in risk between primary surgery and re-operation, 2) which patients may be genetically predisposed to developing the CMS, 3) the effect of corticosteroids, and 4) differences in incidence and clinical course of the CMS according to tumour type, comorbidities, handedness and treatments.\n\nWe hope that the results will contribute to an overall reduction in incidence of the CMS and lead to international harmonization of the treatment of these patients.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
16/NW/0633
Date of REC Opinion
12 Apr 2017
REC opinion
Further Information Favourable Opinion