CMR right ventricular contractile reserve following lung resection
Research type
Research Study
Full title
Assessment of right ventricular contractile reserve following lung resection by dobutamine stress cardiac magnetic resonance: a feasibility study.
IRAS ID
315178
Contact name
Jon Silversides
Contact email
Sponsor organisation
Belfast Health and Social Care Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Background
Lung cancer is the leading cause of cancer related death. Surgery to remove the tumour and the surrounding lung (lung resection) provides the best chance of cure although patients may suffer long-term shortness of breath. This is not solely caused by the loss of part of the lung, but also potentially from a decrease in right heart function (the part of the heart that pumps blood to the lungs).
Right heart function is decreased at rest following lung resection, There is a suggestion that there is a further decrease in right heart function exercise although previous studies investigating this have used unreliable methods.
The cause of the reduced right heart function is not known, it may be the anaesthetic technique (one lung ventilation) used or the removal of lung tissue. Patients undergoing removal of the oesophagus (oesophagectomy) are subject to a similar anaesthetic technique and maybe at risk of right heart damage.
Aims
1. To assess if specialised MRI scans with simulated exercise can accurately measure right heart function before and after lung resection
2. To compare blood test evidence of right heart damage between patients having lung resection, oesophagectomy and major surgery without one lung ventilation.
Methods
We will perform specialised MRI scans of the heart before and two months after lung resection assessing the right heart function at rest and on simulated exercise by giving medication that will temporarily increase the workload of the heart.
We will compare blood markers of right heart damage between patients undergoing surgery to remove part of their lung, oesophagus or other major surgery.
Implications
The results will guide a second, larger, study to assess if impaired right heart function on exercise contributes to shortness of breath following lung resection and if it is caused by one lung ventilation.REC name
HSC REC B
REC reference
23/NI/0029
Date of REC Opinion
28 Mar 2023
REC opinion
Further Information Favourable Opinion