CMR augmented exercise testing in paediatric pulmonary hypertension
Research type
Research Study
Full title
Magnetic resonance augmented exercise testing: a novel biomarker in paediatric pulmonary hypertension.
IRAS ID
152424
Contact name
Vivek Muthurangu
Contact email
Research summary
Paediatric pulmonary hypertension is a serious disease that is both difficult to treat and has a poor prognosis. New therapies are being developed and will hopefully improve survival in this population.
Techniques for assessing pulmonary hypertension in resting children have already been developed at the GOSH/UCL Centre for Cardiovascular Imaging and are now used in clinical practice. However, resting CMR measures do not provide the detailed information needed to subtly refine individual patient management. Exercise CMR may be useful as it evaluates the reserve of the cardiovascular system and because symptoms of pulmonary hypertension often occur or are worse with exercise.
We plan to carry out a study where we ask children and young people aged 8 to 16 years to have a resting Cardiac MRI scan and then to exercise on a MRI safe exercise bike whilst having a continuous MRI scan and measurement of their respiratory airflow, oxygen and carbon dioxide. This is called Cardiac MRI – Cardio Pulmonary Exercise Testing (CMR-CPET).
None of the testing in this study is invasive. All of this study will be conducted in the cardiac MRI department at Great Ormond Street. In the first part of the study we plan to compare a group of healthy children and teenagers and a group with pulmonary hypertension. In the second part of the study we will look at children and teenagers who are having a change in treatment and cardiac catheterisation by the clinical team caring for them. We will add a CMR-CPET at the time of the change of treatment and 6-months after to see if CMR-CPET could be an alternative for these children. The third part of this study is to follow-up children after CMR-CPET for up to 3 years to determine its use in predicting outcome in children with pulmonary hypertension
REC name
London - London Bridge Research Ethics Committee
REC reference
14/LO/0720
Date of REC Opinion
21 Jul 2014
REC opinion
Further Information Favourable Opinion