ClUDo: Clinical Utility of Capsaicin Dose Response Curves
Research type
Research Study
Full title
The Clinical Utility of Capsaicin Dose Response Curves to Discriminate Cough Hyper-responsiveness
IRAS ID
126402
Contact name
Jaclyn Smith
Contact email
Sponsor organisation
University Hospital of South Manchester
Research summary
Cough is a protective reflex which is used to clear the upper airways of irritating material or mucus (phlegm) and yet it is the most common complaint for which people seek medical advice. Most coughs are caused by an infection, such as a cold, which usually settles within 8 weeks. However, some people develop persistent coughing which can last from 8 weeks to several years. This persistent cough is known as ‘chronic cough’.
Chronic cough is a common and troublesome problem and is associated with poor quality of life. Current cough medicines often fail to help people with chronic cough and up to 40% of chronic cough cases have an unknown cause.
The aim of this research is to help us understand why some people develop chronic cough and how their cough compares with healthy individuals. In this study we aim to recruit 96 healthy volunteers split evenly by age and gender and 96 patients with chronic cough. The chronic cough patients will be randomly recruited from our specialist cough clinic. They will not be intentionally matched by age or gender to the healthy controls in order to achieve a representative chronic cough cohort, a large proportion of which are typically female and middle-aged
REC name
North West - Preston Research Ethics Committee
REC reference
13/NW/0400
Date of REC Opinion
2 Jul 2013
REC opinion
Favourable Opinion