Closing volume FOT detect hyperinflation comparing to plethsomography
Research type
Research Study
Full title
Does closing volume (CV) measured by the forced oscillation technique (FOT) reflect early airway closure and hyperinflation in comparison to whole body plethysmography?
IRAS ID
325147
Contact name
Jonathan Fuld
Contact email
Sponsor organisation
Cambridge University Hospitals
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
Dynamic airway closure is a pathophysiological consequence in patients with chronic obstructive pulmonary disease (COPD) resulting in a proportion of inspired volume to become trapped behind closed airways. This is one cardinal feature of the disease contributing to the sensation of breathlessness. Patients therefore require an array of breathing tests to help identify if there is a treatment which may help the resulting breathlessness. One of these tests involves sitting in a sealed box whist performing tricky and demanding breathing maneuvers to measure the severity of the air which is trapped. Recent technology has now been developed which may be able to look at equivalent measurements which are easier for the patient to perform and do to not involving being placed into the sealed box. Using forced oscillatory technique (FOT) of multiple soundwaves being placed though the airway during both tidal breathing and during a vital capacity maneuver, the point in which the airway closes can be measured which is the closing volume (CV). Therefore the closing volume measured using forced oscillatory technique (CVFOT) can be estimated as a substitution for hyperinflation assessment. However, before we are able to offer this test it must be tested against the current measurements being used to help identify if this could be a useful tool for clinicians when treating this patient group.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
23/LO/0637
Date of REC Opinion
17 Aug 2023
REC opinion
Further Information Favourable Opinion