Clinical Oral Manifestations of Ehlers Danlos Syndrome

• Research type

  Research Study

• Full title

  Oral Manifestations of Ehlers-Danlos Syndromes; A Systematic Analysis

• IRAS ID

  303719

• Contact name

  James Scott

• Contact email

  james.scott3@nhs.net

• Sponsor organisation

  Sheffield Teaching Hospitals NHS Foundation Trust

• Duration of Study in the UK

  0 years, 11 months, 30 days

• Research summary

  Ehlers-Danlos Syndrome is an inherited genetic disorder affecting connective tissues of the body. It is widely accepted that individuals diagnosed with one of the fourteen known subtypes of Ehlers-Danlos syndrome (EDS) have a significantly lowered oral health-related quality of life (OHQOL) due to some of the characteristics of the disease. Whilst a number of previous papers have attempted to link clinical findings with OHQOL, they have lacked scientific rigour, either with oral investigations or with genetic clarification of the underlying EDS. This project will employ observational cross-section methodology to measure qualitative and quantitative clinical characteristics in two subtypes of EDS patients; vascular EDS (vEDS) and classic EDS (cEDS). These findings will further our understanding of the oral manifestations of this hereditary connective tissue disorder. They will help inform future guidelines for the management of oral healthcare of EDS patients.

• REC name

  Wales REC 3

• REC reference

  22/WA/0194

• Date of REC Opinion

  26 Jul 2022

• REC opinion

  Further Information Favourable Opinion