Clinical Features & Outcome Predictors in Hospital Acquired Pneumonia
Research type
Research Study
Full title
Clinical Features and Outcome Predictors of Patients with Hospital Acquired Pneumonia
IRAS ID
214428
Contact name
Davinder Dosanjh
Contact email
Sponsor organisation
Heart of England NHS Foundation Trust
Duration of Study in the UK
1 years, 1 months, 5 days
Research summary
Hospital Acquired Pneumonia (HAP) is a major clinical problem, representing an estimated 15-22% of all hospital acquired infections. It is defined as a lung infection in a non-intubated patient with evidence of new infection on chest X-ray >48 hours after hospital admission or within 24 hours of discharge from a previous hospital stay. HAP has high morbidity and mortality rates, with reported mortality ranging between 30 – 70%.
Despite this large burden of disease, little is known about which patients are pre-disposed to HAP, or the prognostic factors once you have been diagnosed with it. There is little published literature regarding demographics, clinical features, prognostic factors or outcomes for patients with a primary HAP diagnosis. There is also no widely used, standardised, validated method of predicting mortality in HAP.
This retrospective study aims to define the population which HAP affects, look at outcomes of these patients and define predictors of mortality.
To achieve this we will describe two patient cohorts with HAP at two, independent, tertiary centres. This will be based on data already collected as part of clinical audit, done to assess adherence to local and national guidelines for the management of patients with HAP. The pseudonymised data will then be reviewed and statistical analysis performed to see if any of the information available to the doctors at the time of diagnosis, could be used to predict how likely the patient is to die during the patient’s hospital admission or within the first year of HAP diagnosis.
REC name
West of Scotland REC 5
REC reference
17/WS/0076
Date of REC Opinion
10 Apr 2017
REC opinion
Favourable Opinion