Clinical CMR Database
Research type
Research Database
IRAS ID
294495
Contact name
Marianna Fontana
Contact email
Research summary
Clinical CMR Database
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
21/EE/0037
Date of REC Opinion
22 Feb 2021
REC opinion
Favourable Opinion
Data collection arrangements
In the study, clinical data will be collected from historic patient records stored on the hospital databases. All imaging data will be collected from the relevant hospital image systems.
All data will be fully de-identified. De-identified research data will be stored securely on the password protected local hospital or affiliated university computer network. All study related files with patient identifiable data will remain on the local hospital network. No identifiable data will be transferred out of the respective Hospital Trusts. Hard copies of study related documentation will be stored securely within the CMR department of the local site. All processing, storage and disposal of data will be in accordance with regulatory requirements including the General Data Protection Regulation (2018). De-identified raw measurement data may be transferred between sites participating in the study and to our collaborating site at the National Institute of Health, Bethesda, USA.
Research programme
Cardiovascular magnetic resonance (CMR) is a rapidly developing tool which is now routinely used in clinical practice to assess characteristics of heart function and anatomy, heart muscle and tissue characteristics, heart damage, blood flow and blood supply to a high level of detail and accuracy. This has allowed for accurate diagnosis and follow up of a wide range of conditions such as ischaemic heart disease, inflammation, scarring, cardiomyopathy, pulmonary hypertension and congenital heart disease. CMR is a proven safe and accurate clinical imaging method, with the possibility of undergoing multiple studies as it delivers no dose of radiation, unlike X-ray based imaging methods such as X-ray and computed tomography (CT). A typical CMR study consists of an immense volume of data containing over 1000 individual images. This provides a wealth of information that we can retrospectively analyse in tandem with de-identified clinical information about individual patients to better understand rarer disease processes, predict future adverse events and even assist in the development of next generation CMR imaging methods. This database of deidentified clinical information and CMR image data would accelerate the development of novel imaging techniques, and facilitate the generation of new knowledge around a wide range heart conditions.
Research database title
Clinical CMR Database
Establishment organisation
Royal Free London NHS Foundation Trust
Establishment organisation address
Royal Free Hospital
Pond Street
London
NW3 2QG