Clinical and Radiological Predictors of Outcome in COVID-19 Patients. [COVID-19]
Research type
Research Study
Full title
Clinical and Radiological Predictors of Outcome and Disease Severity in Patients Treated in Hospital and Later Discharged Following COVID-19 Associated Illness: a retrospective cross-sectional analysis.
IRAS ID
285540
Contact name
David Daley
Contact email
Sponsor organisation
Norfolk & Norwich University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 2 months, 0 days
Research summary
Research into COVID-19 disease has focused on the development of antiviral medications and vaccination. Such therapies will ultimately be fundamental to the future treatment and prevention of the disease. However, in the absence of such therapeutics, there remains an essential need to better understand the pathophysiology of the disease in order to provide optimal care for patients who are unwell in hospital secondary to COVID-19 complications. Whilst the various ways in which COVID-19 presents acutely is becoming increasingly evident as we encounter more unwell patients, there is a fundamental need to investigate which factors, if any, are associated with disease severity and outcome in those patients admitted to secondary care hospitals due to COVID-19 complications. Furthermore, due to a potential high number of patients discharged into the community following an episode of acute illness from COVID-19, there exists an equally vital need to evaluate the long term health consequences of COVID-19 disease through targeted and systematic surveillance of patients recovering from the disease. Data from previous Coronavirus outbreaks has showed evidence of persistent chest x-rays changes weeks and months post discharge. Such findings are now becoming evident in COVID-19 disease. It is therefore important that patients treated for COVID-19 and later discharged are followed up to ensure appropriate management where necessary. We therefore aim to determine the relationship between demographic/clinical parameters, the severity of in-patient chest x-rays and the outcomes of: hospital length of stay, severity of COVID-19 associated illness, disease related morbidity and mortality and the severity of out-patient follow-up chest x-rays.
REC name
London - Riverside Research Ethics Committee
REC reference
20/HRA/3349
Date of REC Opinion
8 Jul 2020
REC opinion
Favourable Opinion