CKD-VANGuARD v1.0
Research type
Research Study
Full title
Prognostication in Chronic Kidney Disease Using Advanced Magnetic Resonance and Cardio-Pulmonary Exercise Testing (CKD-VANGuARD)
IRAS ID
341173
Contact name
Peter Swoboda
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
Magnetic Resonance Imaging (MRI) is a test which produces detailed pictures of your internal organs by putting you within a strong magnetic field. MRI allows us to detect abnormalities in many organs in the human body with a very high sensitivity. Importantly, MRI is a safe test and does not use any harmful radiation. It is therefore an increasingly used test in many areas of medicine with over 100,000 MRI scans performed in the NHS every year.
Cardio-pulmonary exercise testing (CPET) is a test used to assess the response of the heart and lungs to exercise. It is able to accurately identify the underlying cause of an impairment in your exercise tolerance.People living with kidney disease are known to commonly have heart disease, with the relationship between these two conditions complex and not fully understood. By combining advanced MRI techniques and comprehensive exercise testing we hope to better understand the complex relationship between kidney disease and heart disease. In addition, we hope to validate existing markers of adverse outcomes and identify new markers.
By doing this research, we hope in the future to be able to assist in recognising people living with kidney disease who are at high risk of adverse cardiac outcomes and therefore allow them to be monitored and treated more closely than they may otherwise have been.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
24/ES/0040
Date of REC Opinion
19 Jun 2024
REC opinion
Further Information Favourable Opinion