CKD after AKI
Research type
Research Study
Full title
Identification of patients at risk of CKD after AKI
IRAS ID
319992
Contact name
Marlies Ostermann
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Hospital
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
During critical illness, 1 in 2 critically ill patients in the intensive care unit develop kidney failure, also called acute kidney injury. In most cases, kidney function recovers when patients get better. However, recent studies show that some patients who have had acute kidney injury are at high risk of developing chronic kidney failure and needing long-term dialysis treatment several years later, but not everybody is affected. At the moment, there are no good tests to identify patients who are at highest risk so that they can be followed up after discharge from hospital.
We plan to invite patients who had acute kidney injury whilst in ICU and are scheduled to be discharged home to have a urine and blood test to measure some specific molecules and protein. We will ask the patients' GP to check their kidney function and protein level in the urine three months later to find out whether patients have developed signs of chronic kidney failure. We will then check whether the blood and urine results at hospital discharge were different between patients who developed chronic kidney failure and those who didn't.
In addition, we will invite patients to complete a quality of life questionnaire to find out how chronic kidney failure after acute kidney failure affects patients' well-being.The results of this project will tell us whether we can identify those patients who are at highest risk of chronic kidney failure so that they can be prioritised for targeted follow up in future.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
22/SC/0462
Date of REC Opinion
12 Dec 2022
REC opinion
Favourable Opinion