Chronic Musculoskeletal Pain and Dysautonomia
Research type
Research Study
Full title
Chronic Musculoskeletal Pain and Autonomic symptoms Research and Evaluation (COMPARE).
IRAS ID
341932
Contact name
Norah Almutairi
Contact email
Sponsor organisation
University of Leeds
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 11 months, 30 days
Research summary
Chronic Musculoskeletal pain impacts 20–33% of the global population, as indicated by the World Health Organization. In the UK only there are at least 28 million persons who are experiencing chronic pain. Recent studies highlight a significant gap in musculoskeletal chronic pain research, specifically pointing out that the most noticeable shortcomings are observed in outcomes that are not directly related to pain. Many of these non-pain symptoms are related to the Autonomic Nervous system, which oversees a vast range of physiological processes, and recognized as a central player in numerous health issues, including pain.
The COMPARE project, "Chronic Musculoskeletal Pain and Autonomic symptoms Research and Evaluation," aims to examine the prevalence and effects of Autonomic Dysfunction (AD) or Dysautonomia among individuals experiencing chronic musculoskeletal pain. This research seeks to enhance the comprehension of the connections between the autonomic nervous system and musculoskeletal problems, an area that has received limited attention.
This project is divided into two main components: a cross-sectional study and a case-control study. The cross-sectional component aims to determine the prevalence of subjective Autonomic symptoms in CMP patients by employing the Composite Autonomic Symptom Score (COMPASS-31) questionnaire, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale (HADS). In contrast, the case-control study is specifically designed to ascertain the incidence of objective symptoms of AD, utilizing the NASA Lean Test as an assessment tool.REC name
North West - Liverpool Central Research Ethics Committee
REC reference
24/NW/0238
Date of REC Opinion
24 Jul 2024
REC opinion
Further Information Favourable Opinion