Chronic cough in kidney cancer
Research type
Research Study
Full title
Chronic Cough in patients with renal cell carcinoma: The prevalence, trigger, and potential clinical application of chronic cough as an early screening tool in patients with kidney cancer.
IRAS ID
306412
Contact name
Maxine GB Tran
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2022/05/144, Data Protection Number
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Aims:
1) Determine how frequently cough occurs in patients with kidney cancer, relationship to disease and treatment.
2) Assess the impact of cough on quality of life.
3) Test the blood, urine, phlegm, and breath for substances known to cause cough.
4) Detect kidney cancer at earlier, more treatable stage and develop more effective cough treatments.
Background:
Chronic cough affects 10% of the adult population but only half are given a diagnosis (e.g., asthma, gastro-oesophageal reflux, medication). Cough was first associated with kidney cancer in 1935 and may affect 31% of patients; few clinicians are aware of this but within patient forums, the cough resolving once the kidney tumour is treated is widely reported.
Design:
1) Literature review to establish what is known about cough in patients with kidney cancer.
2) Questionnaire to determine how frequently cough occurs in patients attending the specialist centre for kidney cancer. A representative sample will complete the EQ-5D and Leicester Cough Questionnaires and the extent of disease and treatment obtained from the clinical notes. The impact of the cough will be derived from interviews and a focus group.
3) Cough hypersensitivity testing will be performed in consented patients with kidney cancer and "normal" controls. Clinical samples will be analysed for substances that trigger or enhance cough.
Patient/service user, carer, and public involvement:
Involved throughout the study, will provide advice on patient information leaflets, consent forms and questionnaires.
Dissemination:
1) Professionals- open access scientific journals; meetings focused on cough or kidney cancer.
2) Patients/carers- social media, Kidney Cancer UK, Action on Chronic Cough, local hospital events and national kidney cancer patient education days.
Outcome:
1) Establish the prevalence of cough in patients with kidney cancer.
2) Support the education of clinicians to consider this diagnosis in patients with chronic cough.
3) Potential earlier diagnosis of kidney cancer and treatment for coughREC name
London - Surrey Research Ethics Committee
REC reference
22/PR/0791
Date of REC Opinion
22 Aug 2022
REC opinion
Further Information Favourable Opinion