Chronic beta-blockade and cardiopulmonary exercise in COPD, CPET1
Research type
Research Study
Full title
Proof of concept study to assess the differential effects of chronic beta-blockade (celiprolol versus bisoprolol) on cardiopulmonary outcomes at rest and during exercise in chronic obstructive pulmonary disease.
IRAS ID
168125
Contact name
William Anderson
Contact email
Sponsor organisation
University of Dundee
Eudract number
2015-000207-13
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
What are the differential effects of beta-blockers on lung and heart function during exercise in chronic obstructive pulmonary disease (COPD)?
COPD is a major cause of illness and death. Not only do these individuals suffer from lung disease, but COPD often leads to other illnesses, particularly heart disease. Beta-blockers very successfully treat heart disease. It is therefore logical that one would want to use this treatment in COPD patients with heart disease too. However, there has always been concern that beta-blockers could cause significant problems in COPD by worsening lung function, as these can have the opposite effect to inhalers used to treat COPD that open up airways. Pointedly, there is increasing evidence that despite this problem, COPD patients who have been prescribed beta-blockers have been shown to gain benefit particularly in terms of preventing death.
In this study, we therefore want to examine which beta-blocker might be the safest for COPD patients, as each work slightly differently. Some beta-blockers may have a more beneficial effect on airways than others, whilst still benefitting the heart. We will study two different beta-blockers; one that potentially narrows airways and one that potentially opens airways. We will be using cardiopulmonary exercise testing (an exercise bike that measures both heart and lung function during exercise) to look for differences between both beta-blockers primarily in terms of lung function but also with information about the heart. We will recruit people with moderate to severe COPD who are able to complete a cycle exercise test through our respiratory research department. The study will last for 10-12 weeks with 5 main visits to the department for serial exercise tests, breathing tests, simple heart function tests and simple blood tests that will tell us what other effects these beta-blockers are having on the heart and lungs.REC name
East of Scotland Research Ethics Service REC 2
REC reference
15/ES/0102
Date of REC Opinion
17 Sep 2015
REC opinion
Further Information Favourable Opinion