Chromosomal instability biomarkers in Oesophagogastric cancers
Research type
Research Study
Full title
Identification and clinical validation of biomarkers related to chromosomal instability in oesophageal and Gastric cancer
IRAS ID
315795
Contact name
Gianmarco Contino
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Oesophagogastric cancers are included in the top 10 causes of cancer-related deaths in the UK and worldwide. Even after treatment, the risk of cancer returning (i.e. recurrence rate) is 25 - 50% in the first three years. There are two main types of oesophageal cancer: squamous cell carcinoma (SCC) and adenocarcinoma (OAC). Oesophageal adenocarcinoma is the most common of the two in the UK and Western countries. The most common histology type of gastric cancer is gastric adenocarcinoma which can be further classified according to Lauren's classification as intestinal and diffuse.
Studies have shown that the genomes of OAC and GAC, in particular, are characterised by chromosome rearrangements due to chromosomal instability. Chromosomal instability has profound consequences on the molecular mechanisms of the progression of OAC and the host's microenvironment (i.e. the immune system). Our research will investigate oesophageal cancer's genomic and immune landscape to identify novel biomarkers for diagnosis and early detection and therapeutic targets for precision oncology.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
23/PR/0766
Date of REC Opinion
5 Sep 2023
REC opinion
Further Information Favourable Opinion