CHOIR Biobank

• Research type

  Research Tissue Bank

• IRAS ID

  298784

• Research summary

  Childhood Ocular Inflammatory Disease (CHOIR) Biobank

• REC name

  London - City & East Research Ethics Committee

• REC reference

  22/LO/0575

• Date of REC Opinion

  7 Nov 2022

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  The CHOIR biobank samples and data comprise:
  • Blood collected at time of any routine venesection
  • Tears obtained using filter paper strip (Schirmer strip) collection by eye doctor in clinic
  • Tissues considered excess from surgery on the eye including uveal tissue (iris samples) and intraocular fluid (aqueous)
  • Stool / faeces obtained by family at home or by family in clinic
  • Saliva obtained by family at home or by family in clinic
  and routinely collected clinical information.

  Biological data will be stored within UCL ICH laboratories, and clinical information stored within secure UCL IT services.

  Informed consent will be necessary for collection of all samples.

• Research programme

  The CHOIR biobank will support research into childhood onset ocular inflammatory disease: understanding how and why disease develops, and providing the information needed to help develop new treatments (ie 'novel therapeutic strategies'). Key objectives are - the discovery of predictive and prognostic biomarkers (markers which predict who will respond to different treatment, and who will have bad outcomes) to allow better targeting and use of systemic therapy - provision of ocular samples to other researchers, or to companies looking to develop new tests or treatments

• Storage license

  12220

• RTBTitle

  Childhood Ocular Inflammatory Disease (CHOIR) Biobank

• Establishment organisation

  University College London Great Ormond Street Institute of Child Health

• Establishment organisation address

  UCL GOS ICH

  30 Guilford Street

  WC1N 1EH