ChIPS - Chronic Inflammation Post aortic aneurysm Stenting
Research type
Research Study
Full title
Spot measurement of chronic inflammatory markers in patients after endovascular abdominal aortic repair comparing NELLIX system with conventional endovascular stent graft
IRAS ID
148233
Contact name
Paul Hayes
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Research summary
Since the introduction of endovascular repair of aortic aneurysm (EVAR) which is a minimally invasive treatment technique the mortality and morbidity rates improved when compared to previous open repair. One common observation after the endovascular treatment is a systemic inflammatory response called post stent implantation syndrome in which a systemic inflammatory process happens in the body in response to the aneurysm sac clotting off and gets sealed off from blood flow. There are very limited studies with small numbers of patients published in the literature with no analysis done to investigate whether this systemic response has any effects to patients or the stent itself.
We are going to compare two groups of patients by using blood tests only which are going to be done along the routine EVAR follow up. First group are patients with conventional stent graft which leaves the aneurysm sac filled with blood that clots off and the second group are patients treated with a special stent called NELLIX stent which doesn't leave large area to clot off inside the sac and we will compare and analyse the results from both groups and see if there is any adverse effects both on patients or stent implantation.REC name
West of Scotland REC 4
REC reference
14/WS/1010
Date of REC Opinion
20 Jun 2014
REC opinion
Further Information Favourable Opinion