CHIEFTain study
Research type
Research Study
Full title
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis
IRAS ID
307358
Contact name
Marc Dweck
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm disturbances and even death. However, a lot of these conditions are still not fully understood and treatment options are limited. We here aim to use a new radioactive dye called 68Ga-FAPI to identify patterns and the activity of heart muscle scarring. This radioactive dye is being used in humans particularly in identifying and monitoring cancers and has shown promise in identifying scarring in the heart as well. This will help us not only understand the underlying disease process and risk stratify these patients but also potentially help us develop new targeted therapies that can affect heart muscle scarring. Participants will undergo a baseline scan using this new dye and this will be repeated 12-18 months after to see if there are any changes in the process.
REC name
West of Scotland REC 5
REC reference
23/WS/0043
Date of REC Opinion
31 Mar 2023
REC opinion
Further Information Favourable Opinion