CHASE - The COVID-19 HIV Association Study [COVID-19]
Research type
Research Study
Full title
The COVID-19 HIV Association Study – exploring the interplay between HIV clinical history and outcome following SARS-CoV-2 infection.
IRAS ID
282752
Contact name
Anna Maria Geretti
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
3 years, 0 months, 11 days
Research summary
This study aims to explore the interaction between HIV and COVID-19. Specifically, among people with HIV, we aim to link the HIV clinical history with the outcomes of COVID-19 related hospitalisation as collected by the UK component of the ISARIC Clinical Characterisation Protocol. ISARIC CCP is the largest prospective cohort study of people hospitalised with COVID-19 worldwide. Initial analysis of the data from 115 people with HIV within ISARIC CCP-UK has suggested that HIV positive status could increase the risk of mortality following admission with COVID-19. However, the ISARIC dataset provides no information about the HIV clinical history including details of antiretroviral therapy, viral load, current and nadir CD4 cell count, and history of HIV-related disease. These data are essential for us to be able to interpret the ISARIC CCP-UK findings.
This study aims to link the information collected about COVID-19 as part of the ISARIC study with the HIV care history collected by HIV clinics in the UK. In patients who are discharged from hospital, informed consent will be obtained from HIV clinics to fill in a case report form allowing us to link HIV history to COVID-19 outcome. In the case of people with HIV who died during hospital admission consent will be waived. If the clinic regularly submits data to the UK-CHIC study, a cohort study of over 30,000 people with HIV, the CHIC study number will be requested so that the study team can directly retrieve HIV clinical data from UK CHIC.
The study will describe the clinical outcomes of people with HIV who are hospitalised with COVID-19 and importantly evaluate the associations between HIV history with those outcomes. This study is essential to understand why people with HIV may be at increased risk of mortality and to produce evidence-based guidelines for the community of people living with HIV and their clinicians. [Study relying on COPI notice]
REC name
South Central - Oxford A Research Ethics Committee
REC reference
20/SC/0344
Date of REC Opinion
6 Oct 2020
REC opinion
Further Information Favourable Opinion