Characteristics of patients with multiple basal cell carcinomas
Research type
Research Study
Full title
Multiple primary basal cell carcinomas: risk factors, histological subtypes, anatomical distribution, and likelihood of new primary tumors in the same location.
IRAS ID
181476
Contact name
Andrea Zarkovic
Contact email
Sponsor organisation
Wye Valley Trust
Duration of Study in the UK
0 years, 1 months, 13 days
Research summary
Multiple primary basal cell carcinomas: risk factors, anatomical distribution, and likelihood of new primary tumors in the same location.
There are two main aims of the proposed study. Firstly, to describe the characteristics of a population of patients with multiple primary basal cell carcinomas (BCCs) and to identify risk factors for the development of further tumours. Furthermore, we aim to evaluate the likelihood of a subsequent primary BCC developing at the same anatomical site as a previous tumour.
Secondly, we aim to describe histological and anatomical trends in patients with multiple primary BCCs. In particular, to determine the likelihood of the same histological subtype occurring in subsequent primary BCCs as that found in the first tumour and to investigate the risk factors for more aggressive BCC subtypes. We also aim to describe the periocular distribution of BCCs based on their histology.
To address the first set of aims, the study will comprise a retrospective review of all patients who had a histological diagnosis of multiple primary BCCs at Hereford County Hospital between 2009 and 2014. Records of included patients will be reviewed and details of the histology reports will be recorded for all primary BCCs and any other skin malignancies diagnosed over the last 25 years.
To address the second set of study aims detailed above, every patient who had a histological diagnosis of at least two separate primary BCCs from 2009 to 2014 at the Hereford County Hospital will be included in the study. Their histopathology results for all confirmed primary BCC tumours and other skin malignancies over the last 25 years will be recorded.
REC name
North of Scotland Research Ethics Committee 2
REC reference
15/NS/0074
Date of REC Opinion
10 Aug 2015
REC opinion
Further Information Favourable Opinion