Characterisation of the Immune Response to SARS-CoV-2 Infection [COVID-19]
Research type
Research Study
Full title
Characterisation of the Immune Response to SARS-CoV-2 Infection -a study of immunological, virological and host factors that predict outcomes in SARS-CoV-2 infection and COVID disease.
IRAS ID
269506
Contact name
Lucy Jones
Contact email
Sponsor organisation
Cwm Taf Morgannwg University Health board
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
The aim of this project is to understand the host immune response to infection with SARS-CoV-2 over time in convalescent adults, including innate and acquired immune responses, circulating levels of immune signalling molecules, gene expression profiling in peripheral blood and to identify host genetic variants associated with disease progressions or severity.\nParticipants will be healthcare workers who had a diagnosis of COVID (confirmed by positive RT-PCR assay) more than 28 days and have recovered and are employed by Cwm Taf Morgannwg University health board.\nSamples will be processed and analysed to explore immunological, host genetic factors and virological factors that explain pathogenesis and predict outcomes.\n [Study relying on COPI notice]
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
20/HRA/2355
Date of REC Opinion
18 May 2020
REC opinion
Further Information Favourable Opinion