Changes in ingestive behaviour following Roux-en Y gastric bypass

• Research type

  Research Study

• Full title

  Changes in ingestive behaviour following Roux-en-Y gastric bypass

• IRAS ID

  200567

• Contact name

  Ruth Price

• Contact email

  rk.price@ulster.ac.uk

• Clinicaltrials.gov Identifier

  NCT03113305

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  6 years, 0 months, 1 days

• Research summary

  The Roux-en-Y Gastric Bypass (RYGB) procedure is known to be one of the most successful treatments for morbid obesity and Type 2 diabetes mellitus, and has been shown to decrease appetite, energy intake, body weight and glycemia both in the short and long term. A number of reports hypothesise that these changes may be driven, at least in part, by positive shifts in food preferences following surgery. However findings are drawn from self-reported dietary intakes which are beset with measurement bias, thus precluding definite conclusions. The current work aims to directly observe food intake to test the hypothesis that after RYGB intake changes in a manner which leads to beneficial outcomes on body weight when compared to weight stable control participants.
  Patients (n=32) with a planned RYGB procedure will be recruited from Phoenix Health in both Ireland and England, alongside control participants (n=32) with no planned weight loss. All subjects will attend the Human Intervention Studies Unit (HISU), Ulster University on four occasions (1 month pre-surgery and 3, 12 and 24 months post-surgery, with controls being time-matched). Study visits will be fully residential involving two overnight stays within the facility during which participants’ 24-hour food intake will be covertly measured (7am-11pm Day 2 and breakfast Day 3) and the following procedures undertaken; basal metabolic rate, body composition, bone health, assessment of liking/wanting high fat foods (Visit 1, 2 & 4 only) and post-meal gut hormone responses. On each study visit participants will have ad lib access to a range of foods of varying macronutrient composition and which are compatible with their stated food preferences (assessed prior to the start of the study). Changes in all ingestive behaviours will be evaluated over time as compared to the control participants.

• REC name

  West of Scotland REC 3

• REC reference

  16/WS/0056

• Date of REC Opinion

  4 Mar 2016

• REC opinion

  Favourable Opinion