CF-HomeSpIT
Research type
Research Study
Full title
The Cystic Fibrosis Home Sputum-induction Trial (CF-HomeSpIT) - self management for better microbiology surveillance.
IRAS ID
281516
Contact name
Julian T. Forton
Contact email
Sponsor organisation
Cardiff and Vale University Health Board
ISRCTN Number
ISRCTN86523335
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Early infection in children with cystic fibrosis (CF) needs to be treated in order to prevent lung disease. Sampling the lower airway for bacterial pathogens can be difficult in children with CF who are often unable to cough up secretions even if they are unwell and have a wet cough. The CF-SpIT trial showed that the sputum induction procedure is a simple effective approach to sampling lower airway secretions in children, and is as effective as bronchoscopy and bronchoalveolar lavage. The sputum induction procedure involves taking a salt water nebuliser and having chest physiotherapy. This loosens secretions which can then be coughed up.
One important consideration in introducing routine sputum-induction is that it is currently performed by a health professional and takes approximately 30 minutes to perform. Staff resources are therefore a limiting factor to the universal application of the sputum-induction procedure. The Cystic Fibrosis Home Sputum-induction trial (CF Home-SpIT) will compare the microbiology yield from saliva and sputum-induction performed at home by patients and parents, with cough swab, saliva and sputum-induction performed in the clinic, in an attempt to establish home sampling as a valuable addition to standard care in children with CF.
CF-HomeSpIT will recruit Children from the South Wales Cystic Fibrosis Network.REC name
Wales REC 7
REC reference
22/WA/0196
Date of REC Opinion
25 Jul 2022
REC opinion
Favourable Opinion