Central sensitisation
Research type
Research Study
Full title
A prospective open labeled study to evaluate if central sensitization as measured with QST alters following chronic pain interventions
IRAS ID
189438
Contact name
Vivek Mehta
Contact email
Sponsor organisation
Barts Health NHS Trust
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Patients with chronic pain remains a significant burden on the NHS. It is increasingly recognised that medicines/interventions typically provide a modest response in half or fewer of patients treated, and the ability to evaluate the effectiveness of these treatments remains poor. Also the abiliity to predict those patients who will respond and those who do not respond to interventions and treatments. Global outcome measures such as visual analogue scores (VAS) provide a crude integrated measure of a total pain experience but do not identify specific pain mechanisms or differential response of an individual mechanism to a particular treatment. Patients with chronic pain are typically peripherally (touch) and centrally sensitised as measured by quantitative sensory testing (QST). QST offers a powerful tool for explaining pain mechanisms in a variety of clinical and research conditions. The Pain and Anaesthesia Research Centre based at Barts Health NHS Trust is one of a small number of groups worldwide that has clinical experience in using QST in a variety of different clinical and research settings.
In this study we would like to explore whether QST alters with different treatments/interventions and whether QST can be use as a bedside marker for central pain senstisation and whether this is altered with a treatment or intervention.LAY SUMMARY OF STUDY RESULTS:
N/A
Conditioned pain modulation-A comprehensive review.
Ramaswamy S, Wodehouse T.Neurophysiol Clin. 2021 Jun;51(3):197-208. doi: 10.1016/j.neucli.2020.11.002. Epub 2020 Dec 14.REC name
London - South East Research Ethics Committee
REC reference
15/LO/2094
Date of REC Opinion
12 Jan 2016
REC opinion
Further Information Favourable Opinion