CEMARC long-term outcome study

• Research type

  Research Study

• Full title

  Clinical Evaluation of MAgnetic Resonance imaging in Coronary heart disease (CEMARC): long-term outcome study

• IRAS ID

  129299

• Contact name

  John P Greenwood

• Contact email

  j.greenwood@leeds.ac.uk

• Sponsor organisation

  Leeds Teaching Hospital NHS Trust

• Research summary

  CE-MARC was the first large-scale trial of Cardiac Magnetic Resonance Imaging (CMR) for the diagnosis of stable coronary heart disease. 752 patients with suspected stable angina were recruited from March 2006 to August 2009, and underwent imaging with CMR, SPECT (single-photon emission computed tomography) and X-Ray coronary angiography. Patients were followed up for 3 years for major cardiovascular events. The trial established the superior diagnostic accuracy of CMR over SPECT and was published in the Lancet (1).
  The CEMARC study protocol allows for recording of mortality through ONS flagging for an indefinite period. The proposed new study will collect long-term cardiovascular outcome data on the patient cohort for a period of 10 years.

  1. JP Greenwood, N Maredia, JF Younger, JM Brown, J Nixon, CC Everett, P Bijsterveld, JP Ridgway, A Radjenovic, CJ Dickinson, SG Ball, S Plein. CE-MARC: A Prospective Evaluation of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Coronary Heart Disease. Lancet 2012; 379(9814):453-460.

• REC name

  Yorkshire & The Humber - Leeds West Research Ethics Committee

• REC reference

  14/YH/0137

• Date of REC Opinion

  14 May 2014

• REC opinion

  Favourable Opinion