Cellular immunity to herpesvirus infection: Studies with EBV & CMV -v1
Research type
Research Study
Full title
Cellular immunity to herpesvirus infection: Studies with Epstein-Barr virus and human cytomegalovirus
IRAS ID
143798
Contact name
Paul Moss
Contact email
Sponsor organisation
University of Birmingham
Clinicaltrials.gov Identifier
University of Birmingham, ERN_13-1377
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
We are studying the way in which the human immune system, particularly a type of white blood cell known as a T lymphocyte, normally controls infection caused by two human herpesviruses, Epstein-Barr virus (EBV) and cytomegalovirus (CMV). These viruses infect many people and persist for life under the control of the immune system. In the vast majority of cases infection is asymptomatic, but can be life-threatening in immunosuppressed patients. However in some cases primary infection of immunocompetent people is associated with an identifiable acute clinical syndrome, infectious mononucleosis (IM), more commonly known as glandular fever. We wish to make a detailed study of the immune response to EBV and CMV in patients with acute primary infection and in long-term healthy virus carriers. This information will help in the development of future treatments of virus-associated disease in immunosuppressed patients.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
14/WM/1254
Date of REC Opinion
12 Jan 2015
REC opinion
Further Information Favourable Opinion