cEEG and aEEG features predicting poor outcome in neonates with HIE
Research type
Research Study
Full title
A retrospective study to assess features of conventional EEG and amplitude-integrated EEG that predict poor outcome (severe pattern of brain injury on MRI, cerebral palsy, or death) in neonates with hypoxic-ischaemic encephalopathy.
IRAS ID
152652
Contact name
Paul Clarke
Contact email
Sponsor organisation
Norfolk and Norwich University Hospitals NHS Foundation Trust
Research summary
This is a retrospective study of of babies with clinically diagnosed hypoxic-ischaemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH) in the Norfolk & Norwich, Homerton, and Royal London neonatal units.
Aims:
1.To examine early conventional EEG (cEEG) and amplitude-integrated EEG (aEEG) recordings in term/near-term neonates with HIE to identify features that predict poor outcome (as defined below)
2. To devise an early cEEG scoring system applicable for term/near-term neonates with HIE to assist in early prognostication of poor outcome
3. To compare the predictive value of quantifiable measures such as interburst interval and lower aEEG margin amplitude at 24 and 48 hours in order to identify the optimum timing for EEG measures.Study definition of ‘poor outcome’
Includes infants with any one or more of the following:
1.Severe pattern of injury on MR brain scan done within 3 months of birth
2.Abnormal neurodevelopmental outcome on formal neurodevelopmental follow up at age 2 years
3.Death in infancyThe hospitals involved with the study are the Norfolk and Norwich University Hospital, Homerton Hospital and the Royal London Hospital.
Perinatal details, early amplitude integrated EEG (aEEG) data, conventional EEG (cEEG), clinical/neurological examination and 2 year neurodevelopmental follow up will be analysed. All these data are routinely collected as per good standard clinical care and follow up of babies clinically diagnosed with HIE who received TH.Expected outcome:
Currently there is no gold standard EEG scoring system for neonates with HIE. The results of this study will help us better understand EEG features that predict poor outcome (severe pattern of brain injury on MRI/cerebral palsy/death). This may assist clinicians in early prognostication of infants affected by HIE. It will also provide useful clinical information for doctors trying to convey to parents the initial information and test results done on their babies and how they may relate to their future outcome.REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
14/EE/0205
Date of REC Opinion
14 Jul 2014
REC opinion
Further Information Favourable Opinion