cEEG and aEEG features predicting poor outcome in neonates with HIE

  • Research type

    Research Study

  • Full title

    A retrospective study to assess features of conventional EEG and amplitude-integrated EEG that predict poor outcome (severe pattern of brain injury on MRI, cerebral palsy, or death) in neonates with hypoxic-ischaemic encephalopathy.

  • IRAS ID

    152652

  • Contact name

    Paul Clarke

  • Contact email

    paul.clarke@nnuh.nhs.uk

  • Sponsor organisation

    Norfolk and Norwich University Hospitals NHS Foundation Trust

  • Research summary

    This is a retrospective study of of babies with clinically diagnosed hypoxic-ischaemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH) in the Norfolk & Norwich, Homerton, and Royal London neonatal units.

    Aims:
    1.To examine early conventional EEG (cEEG) and amplitude-integrated EEG (aEEG) recordings in term/near-term neonates with HIE to identify features that predict poor outcome (as defined below)
    2. To devise an early cEEG scoring system applicable for term/near-term neonates with HIE to assist in early prognostication of poor outcome
    3. To compare the predictive value of quantifiable measures such as interburst interval and lower aEEG margin amplitude at 24 and 48 hours in order to identify the optimum timing for EEG measures.

    Study definition of ‘poor outcome’
    Includes infants with any one or more of the following:
    1.Severe pattern of injury on MR brain scan done within 3 months of birth
    2.Abnormal neurodevelopmental outcome on formal neurodevelopmental follow up at age 2 years
    3.Death in infancy

    The hospitals involved with the study are the Norfolk and Norwich University Hospital, Homerton Hospital and the Royal London Hospital.
    Perinatal details, early amplitude integrated EEG (aEEG) data, conventional EEG (cEEG), clinical/neurological examination and 2 year neurodevelopmental follow up will be analysed. All these data are routinely collected as per good standard clinical care and follow up of babies clinically diagnosed with HIE who received TH.

    Expected outcome:
    Currently there is no gold standard EEG scoring system for neonates with HIE. The results of this study will help us better understand EEG features that predict poor outcome (severe pattern of brain injury on MRI/cerebral palsy/death). This may assist clinicians in early prognostication of infants affected by HIE. It will also provide useful clinical information for doctors trying to convey to parents the initial information and test results done on their babies and how they may relate to their future outcome.

  • REC name

    East of England - Cambridgeshire and Hertfordshire Research Ethics Committee

  • REC reference

    14/EE/0205

  • Date of REC Opinion

    14 Jul 2014

  • REC opinion

    Further Information Favourable Opinion