CCP-Cancer UK [COVID-19] [UPH]
Research type
Research Study
Full title
CCP-Cancer UK: Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) – a prospective companion study for patients with Cancer and COVID-19.
IRAS ID
285044
Contact name
Carlo Palmieri
Contact email
Sponsor organisation
Clatterbridge Cancer Centre NHS Foundation Trust
ISRCTN Number
ISRCTN15019599
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Currently, there is extremely limited information regarding the risks posed by SARS-CoV-2 virus responsible for COVID19 to patients with cancer. This study aims to understand the presentation, management and outcomes of cancer patients with COVID19. The influence of cancer type and treatment will be explored as well as comparing cancer patients with non-cancer patients. \nThis study will provide valuable information that would educate as well as help inform practice for future possible outbreaks. The information may also inform the development of guidelines with regard to the care and management of cancer patients with viruses such as COVID19 and similar infectious diseases.\nCancer is immunosuppressive, the nature of the immunosuppression seems to be influenced by the microbiota, in addition pulmonary infections are also influenced by the host microbiota, therefore it is important to understand this impact in cancer patients. Analysis of samples from cancer patients with COVID19 offer the opportunity to learn more of these interactions \nThe purpose of CCP-CANCER UK study is to obtain additional data from patients with cancer who were/are recruited into the Principal CCP-UK study which is the key national protocol for characterising COVID19 in the UK population. This study is designed to supplement, not replace, the Principal CCP-UK protocol.\nThis study will be open to research sites who are currently participating in the Principal CCP-UK study.\nThe CCP-Cancer UK study will run for two years. An additional specific cancer data set will be collected from participant’s existing medical records. This cancer specific information when combined with the rich data set related to the COVID-19 episode (derived from CCP-UK) will enable a full understanding of COVID-19 in patients with cancer as well as enable a comparison with non-cancer patients.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
20/EM/0205
Date of REC Opinion
11 Aug 2020
REC opinion
Favourable Opinion