Causes of Acute Coronary Syndrome in People with SCAD or CAE
Research type
Research Study
Full title
Rare coronary phenotypes leading to acute coronary syndromes (ACS): A deep phenotyping study of spontaneous coronary artery dissection (SCAD) and coronary artery aneurysms/ectasia (CAE)
IRAS ID
182079
Contact name
David Adlam
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
5 years, 0 months, 5 days
Research summary
Spontaneous coronary artery dissection (SCAD) and coronary aneurysm ectasia (CAE) are rare and poorly understood conditions affecting the coronary arteries.
We would like to establish a broad study exploring factors that might be connected to SCAD and CAE. Participants will be asked to provide details of their SCAD or CAE and any related medical events and answer questions about the medical and psychological impact of this condition. Researchers will need permission to access the relevant medical records of participating patients including previous angiograms or scans. Patients will then be invited to come to their local participating hospital for clinical assessment (including measurement of height, weight, arm span and leg length) and to undergo further research tests. These may include a cardiovascular MRI and/or CT, ultrasound imaging of the blood vessels, and blood samples including for DNA analysis. To help understand any genetic basis for SCAD and CAE close family members of SCAD and CAE patients may also be invited to consent to blood sampling for DNA analysis. We will ask participants to help us with contacting them. Additionally some patients will be asked to agree to have a skin biopsy. The study seeks to recruit 50 patients with SCAD, 100 patients with CAE, 100 relatives of these patients and 40 age and gender matched healthy volunteers.REC name
London - Queen Square Research Ethics Committee
REC reference
16/LO/0461
Date of REC Opinion
4 May 2016
REC opinion
Further Information Favourable Opinion