Cathepsins in STEMI.
Research type
Research Study
Full title
Cathepsins and heart injury and function in ST elevation myocardial infarction (STEMI).
IRAS ID
131159
Contact name
Colin Berry
Contact email
Sponsor organisation
Golden Jubilee National Hospital
Research summary
Cathepsins are small chemicals made by heart and blood vessel (cardiovascular) cells. At the time of a heart attack, cathepsins may be released from cardiovascular cells. In heart attack patients, it is not known whether or not the levels of cathepsins in the blood are related to the severity of heart muscle injury and/or recovery afterwards.
STEMI patients with an occluded artery and symptom duration less than 6 hours would be eligible to participate. This protocol will bring together information obtained on cathepsin levels in the blood from samples obtained at the time of heart attack treatment and subsequently during follow-up at 2 days and 6 months, combined with contrast-enhanced cardiac MRI scans and subsequently with clinical outcomes in the longer term. Troponin and NT-proBNP which are measures of heart attack injury, will also be measured in the blood samples. After 6 months, clinical follow-up will be performed by electronic case record linkage.
REC name
West of Scotland REC 4
REC reference
14/WS/0085
Date of REC Opinion
26 Jun 2014
REC opinion
Further Information Favourable Opinion